ZFIN is now using GRCz12tu for Genomic Data
Gene
cica
- ID
- ZDB-GENE-060503-700
- Name
- capicua transcriptional repressor a
- Symbol
- cica Nomenclature History
- Previous Names
-
- si:ch211-39e15.1
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in head and telencephalon. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 45. Orthologous to human CIC (capicua transcriptional repressor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 45 | Alliance | Intellectual developmental disorder, autosomal dominant 45 | 617600 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR009071 | High mobility group box domain |
| Domain | IPR058606 | Protein capicua homolog-like, C-terminal tri-helical domain |
| Domain | IPR058607 | Protein capicua homolog-like, high mobility group box |
| Family | IPR052412 | Cell Cycle and Developmental Transcription Regulators |
| Homologous_superfamily | IPR036910 | High mobility group box domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cell Cycle and Developmental Transcription Regulators | High mobility group box domain | High mobility group box domain superfamily | Protein capicua homolog-like, C-terminal tri-helical domain | Protein capicua homolog-like, high mobility group box |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1RP12 | InterPro | 2440 | |||||
| UniProtKB:A0A8M3AJY9 | InterPro | 2293 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers